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ABC is a three-letter acronym that, in the automotive spectrum, may refer to:
- ABC (1906 automobile), an American car
- ABC (1920 automobile), an English car
- ABC Motors, an English car manufacturer
- ABC (1922 automobile), a planned (but never built) American car
- ABC (1999 automotive innovation), Active Body Control, introduced in the 1999 Mercedes-Benz CL500 coupé on the IAA'99 (Internationale Automobilausstellung) in Frankfurt.