For the first time, the Kyalami circuit near Johannesburg was being used. There were some changes in the driver line-ups: John Surtees was driving for Honda, Mike Spence signed for BRM whilst Pedro Rodríguez was on trial for Cooper. Denny Hulme led Jack Brabham away from the start, but the Australian soon spun, handing second place to Surtees, but by lap 21 had managed to regain 2nd. Further down the field, local privateer racer John Love was doing very successfully, rising up to third place in a 4-cylinder Cooper Climax. On lap 41, Brabham retired, followed by Dan Gurney on lap 44. On lap 59, Hulme had to pit for more brake fluid, handing the lead sensationally to Love. A magnificent drive was heartbreakingly halted as with just seven laps left he had to sweep into the pits to take on more fuel. Rodríguez took a fine win for Cooper from Love in second place and Surtees in third.
- Pole position: Jack Brabham - 1:28.3
- Fastest Lap: Denny Hulme - 1:29.9
- Cooper's last Formula 1 victory.